Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1504614..1505226 Replicon chromosome
Accession NZ_LR134293
Organism Streptococcus canis strain NCTC12191

Toxin (Protein)


Gene name parE Uniprot ID A0A4V0C1F2
Locus tag EL097_RS07640 Protein ID WP_003048651.1
Coordinates 1504891..1505226 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4V0C2C3
Locus tag EL097_RS07635 Protein ID WP_003048654.1
Coordinates 1504614..1504901 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL097_RS07615 1499971..1501176 + 1206 WP_003048662.1 30S ribosomal protein S1 -
EL097_RS07620 1501482..1502729 + 1248 WP_039994860.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
EL097_RS07625 1502841..1503809 - 969 WP_003048658.1 polysaccharide deacetylase family protein -
EL097_RS07630 1503995..1504437 + 443 Protein_1411 hypothetical protein -
EL097_RS07635 1504614..1504901 + 288 WP_003048654.1 hypothetical protein Antitoxin
EL097_RS07640 1504891..1505226 + 336 WP_003048651.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL097_RS07645 1505849..1506704 + 856 Protein_1414 homoserine kinase -
EL097_RS07650 1506795..1508063 + 1269 WP_003048649.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -
EL097_RS07655 1508095..1508661 + 567 WP_003048647.1 GTP cyclohydrolase I FolE -
EL097_RS07660 1508670..1509470 + 801 WP_129545009.1 dihydropteroate synthase -
EL097_RS07665 1509477..1509836 + 360 WP_003048644.1 dihydroneopterin aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13215.04 Da        Isoelectric Point: 6.2385

>T287460 WP_003048651.1 NZ_LR134293:1504891-1505226 [Streptococcus canis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLKVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPARSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10977.54 Da        Isoelectric Point: 4.6036

>AT287460 WP_003048654.1 NZ_LR134293:1504614-1504901 [Streptococcus canis]
MVEVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0C1F2

Antitoxin

Source ID Structure
AlphaFold DB A0A4V0C2C3

References