Detailed information of TA system TA287458

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 3748993..3750425
• Replicon: chromosome
• Accession: NZ_LR134290
• Organism: Pseudomonas mendocina strain NCTC10897

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EL191_RS17440
• Protein ID: WP_041979741.1
• Coordinates: 3749856..3750425 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A550EBN6
• Locus tag: EL191_RS17435
• Protein ID: WP_041979742.1
• Coordinates: 3748993..3749850 (-)
• Length: 286 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL191_RS17420	3745915..3746820	-	906	WP_041979747.1	hypothetical protein	-
EL191_RS17425	3746831..3747403	-	573	WP_041979745.1	LemA family protein	-
EL191_RS17430	3747593..3748930	+	1338	WP_041979743.1	peptidase	-
EL191_RS17435	3748993..3749850	-	858	WP_041979742.1	AraC family transcriptional regulator	Antitoxin
EL191_RS17440	3749856..3750425	-	570	WP_041979741.1	GNAT family N-acetyltransferase	Toxin
EL191_RS17445	3750628..3754116	+	3489	WP_041979740.1	hybrid sensor histidine kinase/response regulator	-
EL191_RS17450	3754172..3754981	-	810	WP_026042105.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (14-146)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (17-145)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21495.64 Da
• Isoelectric Point: 7.1691

>T287458 WP_041979741.1 NZ_LR134290:c3750425-3749856 [Pseudomonas mendocina]
MFKPQLVTLQRGALRLEPLSDADIPALVALAEANREELLYMSGTQRLDWYRSALADLREQRALPFVIRLGDELVGTTRFA
DFMNTLPACEIGWTWLDRNQYGSGLNTTIKYLMLRHAFDNWGMVRVQLKTAASNQRSQRAIEKLGAVREGLLRNHRRLAD
GRLDDTVLYSITDLEWPALREAMEAGFGA

Nucleotide

• Length: 570 bp

Antitoxin

Protein

• Length: 286 a.a.
• Molecular weight: 31735.12 Da
• Isoelectric Point: 9.0437

>AT287458 WP_041979742.1 NZ_LR134290:c3749850-3748993 [Pseudomonas mendocina]
MQAREQTRFWQASALSGVELLQARYLEQRFAPHVHEGFVFTVIEHGAQRFHHRGSDHLAPQGSMVLINPDEVHTGSKAHE
DGWRYRGFYPGNDQVLGALQELGLAKTGMPSFSFSVLHDPQLHSAFLQLHRLLDGGAEALQQQLAWREAILLLFQRHARL
AEPAAPGREPWAVACAKQMLADRLIEPPSLEELAAAVNLSPFHFARVFRRATGLPPHAWLKQRRLEQARALLKTGCTAVT
VATQLGFADQSHLSRQFKQVYGVSPGEYRSAVARIVAEGAPPGER

Nucleotide

• Length: 858 bp

Structures

Antitoxin

• AlphaFold DB: A0A550EBN6