Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4881509..4882166 Replicon chromosome
Accession NZ_LR134280
Organism Klebsiella pneumoniae strain NCTC9793

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EL169_RS24520 Protein ID WP_002916310.1
Coordinates 4881756..4882166 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EL169_RS24515 Protein ID WP_002916312.1
Coordinates 4881509..4881775 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL169_RS24490 4876665..4878098 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
EL169_RS24495 4878217..4878945 - 729 WP_023313614.1 MurR/RpiR family transcriptional regulator -
EL169_RS24500 4878995..4879306 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
EL169_RS24505 4879470..4880129 + 660 WP_002916317.1 hemolysin III family protein -
EL169_RS24510 4880280..4881263 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
EL169_RS24515 4881509..4881775 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EL169_RS24520 4881756..4882166 + 411 WP_002916310.1 protein YgfX Toxin
EL169_RS24525 4882173..4882694 - 522 WP_002916308.1 flavodoxin FldB -
EL169_RS24530 4882795..4883691 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
EL169_RS24535 4883714..4884427 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL169_RS24540 4884433..4886166 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T287453 WP_002916310.1 NZ_LR134280:4881756-4882166 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT287453 WP_002916312.1 NZ_LR134280:4881509-4881775 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References