Detailed information of TA system TA287449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3634033..3635714
• Replicon: chromosome
• Accession: NZ_LR134280
• Organism: Klebsiella pneumoniae strain NCTC9793

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A2L0KL13
• Locus tag: EL169_RS18265
• Protein ID: WP_019704723.1
• Coordinates: 3634033..3634950 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: EL169_RS18270
• Protein ID: WP_004177809.1
• Coordinates: 3634956..3635714 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL169_RS18245	3629339..3630859	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
EL169_RS18250	3630856..3631854	+	999	WP_002885172.1	ribose ABC transporter permease	-
EL169_RS18255	3631885..3632826	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
EL169_RS18260	3632901..3633908	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
EL169_RS18265	3634033..3634950	-	918	WP_019704723.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EL169_RS18270	3634956..3635714	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
EL169_RS18275	3635800..3636528	-	729	WP_040181498.1	response regulator transcription factor	-
EL169_RS18280	3636801..3638948	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
EL169_RS18285	3639178..3639864	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34632.07 Da
• Isoelectric Point: 5.4707

>T287449 WP_019704723.1 NZ_LR134280:c3634950-3634033 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT287449 WP_004177809.1 NZ_LR134280:c3635714-3634956 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A0A2L0KL13

Antitoxin

• AlphaFold DB: A6TH05