Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3464772..3465288 Replicon chromosome
Accession NZ_LR134280
Organism Klebsiella pneumoniae strain NCTC9793

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag EL169_RS17395 Protein ID WP_004178374.1
Coordinates 3464772..3465056 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag EL169_RS17400 Protein ID WP_002886901.1
Coordinates 3465046..3465288 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL169_RS17375 3460189..3460497 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
EL169_RS27325 3460582..3460755 + 174 WP_002886906.1 hypothetical protein -
EL169_RS17380 3460758..3461501 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
EL169_RS17385 3461858..3463996 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
EL169_RS17390 3464304..3464768 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EL169_RS17395 3464772..3465056 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL169_RS17400 3465046..3465288 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL169_RS17405 3465366..3467276 - 1911 WP_040236557.1 BglG family transcription antiterminator -
EL169_RS17410 3467299..3468453 - 1155 WP_023159544.1 lactonase family protein -
EL169_RS17415 3468520..3469260 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T287448 WP_004178374.1 NZ_LR134280:c3465056-3464772 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT287448 WP_002886901.1 NZ_LR134280:c3465288-3465046 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References