Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1378076..1379664 Replicon chromosome
Accession NZ_LR134280
Organism Klebsiella pneumoniae strain NCTC9793

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL169_RS07285 Protein ID WP_032436337.1
Coordinates 1378076..1379398 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag EL169_RS07290 Protein ID WP_002904790.1
Coordinates 1379398..1379664 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL169_RS07265 1373133..1375634 + 2502 WP_032436339.1 fimbrial biogenesis outer membrane usher protein -
EL169_RS07270 1375622..1376626 + 1005 WP_032436338.1 type 1 fimbrial protein -
EL169_RS07280 1376767..1378059 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
EL169_RS07285 1378076..1379398 - 1323 WP_032436337.1 type II toxin-antitoxin system HipA family toxin Toxin
EL169_RS07290 1379398..1379664 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EL169_RS07295 1380051..1380377 - 327 WP_032436336.1 hydroxyisourate hydrolase -
EL169_RS07300 1380374..1380874 - 501 WP_032436335.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EL169_RS07305 1380852..1382231 - 1380 WP_032412205.1 purine permease -
EL169_RS07310 1382577..1383731 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
EL169_RS07315 1383712..1384635 - 924 WP_032436334.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49106.39 Da        Isoelectric Point: 7.5617

>T287445 WP_032436337.1 NZ_LR134280:c1379398-1378076 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT287445 WP_002904790.1 NZ_LR134280:c1379664-1379398 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References