Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1436250..1436709 Replicon chromosome
Accession NZ_LR134274
Organism Streptococcus salivarius strain NCTC8618

Toxin (Protein)


Gene name relE Uniprot ID A0A448ACE6
Locus tag EL086_RS06975 Protein ID WP_038676362.1
Coordinates 1436250..1436504 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8LI53
Locus tag EL086_RS06980 Protein ID WP_013990356.1
Coordinates 1436494..1436709 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL086_RS06945 1431448..1432203 + 756 WP_038676355.1 ABC transporter permease -
EL086_RS06950 1432255..1432827 - 573 WP_072903575.1 DUF4352 domain-containing protein -
EL086_RS06955 1432974..1433849 - 876 WP_038676357.1 HAMP domain-containing histidine kinase -
EL086_RS06960 1433849..1434532 - 684 WP_014632931.1 response regulator transcription factor -
EL086_RS06965 1434696..1435328 - 633 WP_021143918.1 nitroreductase family protein -
EL086_RS06970 1435419..1436105 - 687 WP_038676360.1 DUF1275 domain-containing protein -
EL086_RS06975 1436250..1436504 - 255 WP_038676362.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL086_RS06980 1436494..1436709 - 216 WP_013990356.1 hypothetical protein Antitoxin
EL086_RS06985 1436840..1437682 - 843 WP_038676364.1 aldo/keto reductase -
EL086_RS06990 1437817..1438818 - 1002 WP_038676367.1 UDP-glucose 4-epimerase GalE -
EL086_RS06995 1438930..1440540 - 1611 WP_038676369.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-57)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9876.63 Da        Isoelectric Point: 11.1183

>T287440 WP_038676362.1 NZ_LR134274:c1436504-1436250 [Streptococcus salivarius]
MTYKIVPTPKFAKSFKKLDPFVRKQIKSYLNRITDNPRAKGKALVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8016.98 Da        Isoelectric Point: 3.8852

>AT287440 WP_013990356.1 NZ_LR134274:c1436709-1436494 [Streptococcus salivarius]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLDAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448ACE6

Antitoxin

Source ID Structure
AlphaFold DB F8LI53

References