Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2184263..2184792 Replicon chromosome
Accession NZ_LR134271
Organism Staphylococcus aureus strain NCTC7988

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL099_RS11365 Protein ID WP_000621175.1
Coordinates 2184263..2184625 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag EL099_RS11370 Protein ID WP_000948331.1
Coordinates 2184622..2184792 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL099_RS11340 2181241..2182011 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
EL099_RS11345 2181986..2182465 - 480 WP_001190825.1 anti-sigma B factor RsbW -
EL099_RS11350 2182467..2182793 - 327 WP_001052491.1 anti-sigma factor antagonist -
EL099_RS11355 2182912..2183913 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
EL099_RS11365 2184263..2184625 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL099_RS11370 2184622..2184792 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EL099_RS11375 2184877..2186025 - 1149 WP_001281150.1 alanine racemase -
EL099_RS11380 2186091..2186450 - 360 WP_000581198.1 holo-ACP synthase -
EL099_RS11385 2186454..2186945 - 492 WP_001286982.1 PH domain-containing protein -
EL099_RS11390 2186938..2188515 - 1578 WP_070040361.1 PH domain-containing protein -
EL099_RS11395 2188508..2188987 - 480 WP_001287084.1 hypothetical protein -
EL099_RS11400 2189196..2189756 - 561 WP_001092415.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T287432 WP_000621175.1 NZ_LR134271:c2184625-2184263 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT287432 WP_000948331.1 NZ_LR134271:c2184792-2184622 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References