Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1954128..1954904 Replicon chromosome
Accession NZ_LR134271
Organism Staphylococcus aureus strain NCTC7988

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag EL099_RS09920 Protein ID WP_000031108.1
Coordinates 1954128..1954280 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag EL099_RS09925 Protein ID WP_001251219.1
Coordinates 1954305..1954904 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL099_RS09895 1950137..1950958 + 822 WP_000669385.1 RluA family pseudouridine synthase -
EL099_RS09900 1951409..1952794 - 1386 WP_000116236.1 class II fumarate hydratase -
EL099_RS09905 1952990..1953385 - 396 WP_000901023.1 hypothetical protein -
EL099_RS09920 1954128..1954280 - 153 WP_000031108.1 hypothetical protein Toxin
EL099_RS09925 1954305..1954904 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
EL099_RS09930 1955063..1955533 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL099_RS09935 1955538..1956665 - 1128 WP_070040394.1 tRNA epoxyqueuosine(34) reductase QueG -
EL099_RS09940 1956816..1957538 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
EL099_RS09945 1957531..1958988 - 1458 WP_000649892.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T287431 WP_000031108.1 NZ_LR134271:c1954280-1954128 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT287431 WP_001251219.1 NZ_LR134271:c1954904-1954305 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References