Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3956501..3957299 Replicon chromosome
Accession NZ_LR134270
Organism Escherichia marmotae strain NCTC8196

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag EL146_RS19270 Protein ID WP_115425318.1
Coordinates 3956922..3957299 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EL146_RS19265 Protein ID WP_126511418.1
Coordinates 3956501..3956875 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL146_RS19245 3954161..3954979 + 819 WP_126511414.1 DUF945 domain-containing protein -
EL146_RS19250 3955071..3955556 + 486 WP_126511415.1 antirestriction protein -
EL146_RS19255 3955572..3956048 + 477 WP_126511416.1 RadC family protein -
EL146_RS19260 3956117..3956338 + 222 WP_126511417.1 DUF987 domain-containing protein -
EL146_RS19265 3956501..3956875 + 375 WP_126511418.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL146_RS19270 3956922..3957299 + 378 WP_115425318.1 TA system toxin CbtA family protein Toxin
EL146_RS19275 3957296..3957784 + 489 WP_059252050.1 hypothetical protein -
EL146_RS19280 3957796..3957993 + 198 WP_000839282.1 DUF957 domain-containing protein -
EL146_RS19285 3958078..3958923 + 846 WP_126511475.1 DUF4942 domain-containing protein -
EL146_RS19295 3959224..3959730 + 507 WP_000227305.1 G/U mismatch-specific DNA glycosylase -
EL146_RS19300 3959810..3961651 - 1842 WP_000437384.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14173.15 Da        Isoelectric Point: 6.9576

>T287425 WP_115425318.1 NZ_LR134270:3956922-3957299 [Escherichia marmotae]
MKTLPDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13787.60 Da        Isoelectric Point: 6.7387

>AT287425 WP_126511418.1 NZ_LR134270:3956501-3956875 [Escherichia marmotae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References