Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3812158..3812809 Replicon chromosome
Accession NZ_LR134270
Organism Escherichia marmotae strain NCTC8196

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag EL146_RS18615 Protein ID WP_126511403.1
Coordinates 3812158..3812562 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U9H610
Locus tag EL146_RS18620 Protein ID WP_000354045.1
Coordinates 3812543..3812809 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL146_RS18595 3808122..3809855 - 1734 WP_000813173.1 single-stranded-DNA-specific exonuclease RecJ -
EL146_RS18600 3809861..3810571 - 711 WP_000715232.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL146_RS18605 3810596..3811492 - 897 WP_000806649.1 site-specific tyrosine recombinase XerD -
EL146_RS18610 3811603..3812124 + 522 WP_016249162.1 flavodoxin FldB -
EL146_RS18615 3812158..3812562 - 405 WP_126511403.1 protein YgfX Toxin
EL146_RS18620 3812543..3812809 - 267 WP_000354045.1 FAD assembly factor SdhE Antitoxin
EL146_RS18625 3813062..3814042 + 981 WP_000886070.1 tRNA-modifying protein YgfZ -
EL146_RS18630 3814189..3814848 - 660 WP_001517030.1 hemolysin III family protein -
EL146_RS18635 3815011..3815322 - 312 WP_001182960.1 N(4)-acetylcytidine aminohydrolase -
EL146_RS18640 3815367..3816800 + 1434 WP_001517031.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 16103.06 Da        Isoelectric Point: 11.5202

>T287424 WP_126511403.1 NZ_LR134270:c3812562-3812158 [Escherichia marmotae]
VVLWQSELRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINSRQGEIRLLMDWRLRWQGQ
EWSIVKTPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRIVLQQEIR

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10533.09 Da        Isoelectric Point: 5.1496

>AT287424 WP_000354045.1 NZ_LR134270:c3812809-3812543 [Escherichia marmotae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H610

References