Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2503248..2503886 Replicon chromosome
Accession NZ_LR134270
Organism Escherichia marmotae strain NCTC8196

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag EL146_RS12265 Protein ID WP_000813795.1
Coordinates 2503710..2503886 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL146_RS12260 Protein ID WP_077627724.1
Coordinates 2503248..2503664 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL146_RS12240 2498403..2499344 - 942 WP_001516417.1 ABC transporter permease -
EL146_RS12245 2499345..2500358 - 1014 WP_016248715.1 ABC transporter ATP-binding protein -
EL146_RS12250 2500376..2501521 - 1146 WP_000047463.1 ABC transporter substrate-binding protein -
EL146_RS12255 2501760..2503169 - 1410 WP_016248716.1 PLP-dependent aminotransferase family protein -
EL146_RS12260 2503248..2503664 - 417 WP_077627724.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL146_RS12265 2503710..2503886 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL146_RS12270 2504108..2504338 + 231 WP_000494240.1 DUF2554 family protein -
EL146_RS12275 2504432..2506393 - 1962 WP_024193578.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL146_RS12280 2506466..2507002 - 537 WP_001516421.1 XRE family transcriptional regulator -
EL146_RS12285 2507055..2508266 + 1212 WP_071990339.1 benzoate/H(+) symporter BenE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T287422 WP_000813795.1 NZ_LR134270:c2503886-2503710 [Escherichia marmotae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15250.62 Da        Isoelectric Point: 4.5908

>AT287422 WP_077627724.1 NZ_LR134270:c2503664-2503248 [Escherichia marmotae]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNNNDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References