Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1292849..1293467 Replicon chromosome
Accession NZ_LR134270
Organism Escherichia marmotae strain NCTC8196

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag EL146_RS06230 Protein ID WP_001280991.1
Coordinates 1292849..1293067 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U9DNY0
Locus tag EL146_RS06235 Protein ID WP_000344801.1
Coordinates 1293072..1293467 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL146_RS06195 1288143..1288715 + 573 WP_016248421.1 YbaY family lipoprotein -
EL146_RS06200 1288746..1289057 - 312 WP_000409903.1 MGMT family protein -
EL146_RS06210 1289437..1289790 + 354 WP_000878149.1 DUF1428 domain-containing protein -
EL146_RS06215 1289827..1291377 - 1551 WP_001515896.1 EAL domain-containing protein -
EL146_RS06220 1291541..1292011 - 471 WP_010379081.1 YlaC family protein -
EL146_RS06225 1292126..1292677 - 552 WP_000102537.1 maltose O-acetyltransferase -
EL146_RS06230 1292849..1293067 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
EL146_RS06235 1293072..1293467 - 396 WP_000344801.1 Hha toxicity modulator TomB Antitoxin
EL146_RS06240 1294024..1297172 - 3149 Protein_1186 efflux RND transporter permease AcrB -
EL146_RS06245 1297195..1298388 - 1194 WP_001515899.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T287415 WP_001280991.1 NZ_LR134270:c1293067-1292849 [Escherichia marmotae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 15393.22 Da        Isoelectric Point: 4.9228

>AT287415 WP_000344801.1 NZ_LR134270:c1293467-1293072 [Escherichia marmotae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSCSNYYNHG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DNY0

References