Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 730805..731381 Replicon chromosome
Accession NZ_LR134270
Organism Escherichia marmotae strain NCTC8196

Toxin (Protein)


Gene name shpA Uniprot ID A0A7U9H5P0
Locus tag EL146_RS03550 Protein ID WP_016249550.1
Coordinates 730805..731092 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A7U9DAW4
Locus tag EL146_RS03555 Protein ID WP_000063150.1
Coordinates 731079..731381 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL146_RS03535 726384..727769 - 1386 WP_016249547.1 restriction endonuclease subunit S -
EL146_RS03540 727756..729378 - 1623 WP_016249548.1 type I restriction-modification system subunit M -
EL146_RS03545 729442..730608 - 1167 WP_016249549.1 restriction endonuclease -
EL146_RS03550 730805..731092 + 288 WP_016249550.1 BrnT family toxin Toxin
EL146_RS03555 731079..731381 + 303 WP_000063150.1 BrnA antitoxin family protein Antitoxin
EL146_RS03560 731415..732371 - 957 WP_001297640.1 GTPase -
EL146_RS03565 732382..732585 - 204 WP_000467859.1 YbdD/YjiX family protein -
EL146_RS03570 732705..734855 - 2151 WP_016249551.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11082.59 Da        Isoelectric Point: 8.6424

>T287413 WP_016249550.1 NZ_LR134270:730805-731092 [Escherichia marmotae]
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRVGNGEYRWQTIGLVHGIVVILVAHIIRFESGNEIIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11532.03 Da        Isoelectric Point: 9.4646

>AT287413 WP_000063150.1 NZ_LR134270:731079-731381 [Escherichia marmotae]
MSMVKHKRGTPSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9H5P0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DAW4

References