Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 431807..432303 Replicon chromosome
Accession NZ_LR134270
Organism Escherichia marmotae strain NCTC8196

Toxin (Protein)


Gene name ghoT Uniprot ID A0A7U9DCZ4
Locus tag EL146_RS02100 Protein ID WP_001173345.1
Coordinates 432130..432303 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A7U9DAJ1
Locus tag EL146_RS02095 Protein ID WP_001517605.1
Coordinates 431807..432103 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL146_RS02075 428539..429258 - 720 WP_000611294.1 two-component system response regulator DcuR -
EL146_RS02080 429255..430886 - 1632 WP_001216442.1 sensor histidine kinase -
EL146_RS02085 431065..431295 + 231 WP_000371696.1 (4Fe-4S)-binding protein -
EL146_RS02090 431307..431579 + 273 WP_000405652.1 N-acetyltransferase -
EL146_RS02095 431807..432103 + 297 WP_001517605.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
EL146_RS02100 432130..432303 + 174 WP_001173345.1 type V toxin-antitoxin system toxin GhoT Toxin
EL146_RS02105 432422..433939 - 1518 WP_001295074.1 lysine--tRNA ligase -
EL146_RS02110 434176..435633 - 1458 WP_001517606.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 431807..441104 9297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(7-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T287412 WP_001173345.1 NZ_LR134270:432130-432303 [Escherichia marmotae]
MALFSKILIFYVIGVNISFVIIWFLSHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11568.18 Da        Isoelectric Point: 4.0994

>AT287412 WP_001517605.1 NZ_LR134270:431807-432103 [Escherichia marmotae]
MEGINRFKTYVVSFDYPSSYYSVFLRLRSLMYDMDFSSIVADEYGIPRQLNENAFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMIVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DCZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DAJ1

References