Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 811192..811721 Replicon chromosome
Accession NZ_LR134269
Organism Staphylococcus warneri strain NCTC11044

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag EL082_RS03940 Protein ID WP_002451625.1
Coordinates 811359..811721 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag EL082_RS03935 Protein ID WP_002451626.1
Coordinates 811192..811362 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL082_RS03910 807017..807490 + 474 WP_002466763.1 PH domain-containing protein -
EL082_RS03915 807483..809009 + 1527 WP_164553444.1 PH domain-containing protein -
EL082_RS03920 808996..809499 + 504 WP_015364833.1 PH domain-containing protein -
EL082_RS03925 809526..809900 + 375 WP_002466788.1 holo-ACP synthase -
EL082_RS03930 809952..811100 + 1149 WP_015364834.1 alanine racemase -
EL082_RS03935 811192..811362 + 171 WP_002451626.1 hypothetical protein Antitoxin
EL082_RS03940 811359..811721 + 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL082_RS03950 812044..813044 + 1001 Protein_777 PP2C family protein-serine/threonine phosphatase -
EL082_RS03955 813138..813464 + 327 WP_002466754.1 anti-sigma factor antagonist -
EL082_RS03960 813466..813945 + 480 WP_049414624.1 anti-sigma B factor RsbW -
EL082_RS03965 813920..814690 + 771 WP_002451621.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T287407 WP_002451625.1 NZ_LR134269:811359-811721 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT287407 WP_002451626.1 NZ_LR134269:811192-811362 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References