287405

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 814900..815424 Replicon chromosome
Accession NZ_LR134267
Organism Staphylococcus pseudintermedius strain NCTC5661

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag EL085_RS03575 Protein ID WP_014613379.1
Coordinates 815071..815424 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag EL085_RS03570 Protein ID WP_014613378.1
Coordinates 814900..815070 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL085_RS03545 810789..811262 + 474 WP_014613373.1 PH domain-containing protein -
EL085_RS03550 811255..812784 + 1530 WP_014613374.1 PH domain-containing protein -
EL085_RS03555 812768..813286 + 519 WP_014613375.1 PH domain-containing protein -
EL085_RS03560 813283..813633 + 351 WP_014613376.1 holo-ACP synthase -
EL085_RS03565 813667..814815 + 1149 WP_126510888.1 alanine racemase -
EL085_RS03570 814900..815070 + 171 WP_014613378.1 hypothetical protein Antitoxin
EL085_RS03575 815071..815424 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL085_RS03580 815482..816486 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
EL085_RS03585 816565..816891 + 327 WP_014613381.1 anti-sigma factor antagonist -
EL085_RS03590 816891..817370 + 480 WP_031253870.1 anti-sigma B factor RsbW -
EL085_RS03595 817345..818115 + 771 WP_014613383.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T287405 WP_014613379.1 NZ_LR134267:815071-815424 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT287405 WP_014613378.1 NZ_LR134267:814900-815070 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References