Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 799984..800505 Replicon chromosome
Accession NZ_LR134267
Organism Staphylococcus pseudintermedius strain NCTC5661

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag EL085_RS03505 Protein ID WP_014613364.1
Coordinates 800284..800505 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag EL085_RS03500 Protein ID WP_014613363.1
Coordinates 799984..800271 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL085_RS03475 795245..796048 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
EL085_RS03480 796038..796676 + 639 WP_014613359.1 thiamine phosphate synthase -
EL085_RS03485 796765..797631 + 867 WP_014613360.1 membrane protein insertase YidC -
EL085_RS03490 797685..798341 - 657 WP_063279128.1 HD domain-containing protein -
EL085_RS03495 798362..799852 - 1491 WP_014613362.1 cardiolipin synthase -
EL085_RS03500 799984..800271 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL085_RS03505 800284..800505 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
EL085_RS03510 800509..800715 + 207 WP_014613365.1 cation transporter -
EL085_RS03515 800816..802996 + 2181 WP_063279127.1 heavy metal translocating P-type ATPase -
EL085_RS12085 803082..803228 + 147 WP_014613367.1 hypothetical protein -
EL085_RS03520 804196..804924 + 729 WP_014613368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T287404 WP_014613364.1 NZ_LR134267:800284-800505 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT287404 WP_014613363.1 NZ_LR134267:799984-800271 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References