Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 978960..979474 Replicon chromosome
Accession NZ_LR134264
Organism Staphylococcus simulans strain NCTC7944

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL095_RS04375 Protein ID WP_031262808.1
Coordinates 979124..979474 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4QNU3
Locus tag EL095_RS04370 Protein ID WP_023016097.1
Coordinates 978960..979127 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL095_RS04345 974850..975314 + 465 WP_060804059.1 PH domain-containing protein -
EL095_RS04350 975307..976800 + 1494 WP_126497989.1 PH domain-containing protein -
EL095_RS04355 976793..977290 + 498 WP_070626486.1 PH domain-containing protein -
EL095_RS04360 977292..977645 + 354 WP_070626517.1 holo-ACP synthase -
EL095_RS04365 977725..978879 + 1155 WP_070626485.1 alanine racemase -
EL095_RS04370 978960..979127 + 168 WP_023016097.1 hypothetical protein Antitoxin
EL095_RS04375 979124..979474 + 351 WP_031262808.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL095_RS04380 979766..980767 + 1002 WP_126497990.1 PP2C family protein-serine/threonine phosphatase -
EL095_RS04385 980843..981169 + 327 WP_002481749.1 anti-sigma factor antagonist -
EL095_RS04390 981171..981650 + 480 WP_023016096.1 anti-sigma B factor RsbW -
EL095_RS04395 981625..982395 + 771 WP_002481747.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.09 Da        Isoelectric Point: 10.0474

>T287398 WP_031262808.1 NZ_LR134264:979124-979474 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Download         Length: 351 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6257.78 Da        Isoelectric Point: 3.6836

>AT287398 WP_023016097.1 NZ_LR134264:978960-979127 [Staphylococcus simulans]
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4QNU3

References