Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 965662..966176 Replicon chromosome
Accession NZ_LR134264
Organism Staphylococcus simulans strain NCTC7944

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag EL095_RS04310 Protein ID WP_002481764.1
Coordinates 965970..966176 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag EL095_RS04305 Protein ID WP_002481765.1
Coordinates 965662..965955 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL095_RS04280 961057..961695 + 639 WP_070626492.1 thiamine phosphate synthase -
EL095_RS04285 961784..962653 + 870 WP_002481769.1 membrane protein insertase YidC -
EL095_RS04290 962779..963291 + 513 WP_126497986.1 GNAT family N-acetyltransferase -
EL095_RS04295 963348..963998 - 651 WP_126497987.1 HD domain-containing protein -
EL095_RS04300 964022..965503 - 1482 WP_023016108.1 cardiolipin synthase -
EL095_RS04305 965662..965955 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL095_RS04310 965970..966176 + 207 WP_002481764.1 heavy-metal-associated domain-containing protein Toxin
EL095_RS04315 966195..966401 + 207 WP_002481763.1 copper ion binding protein -
EL095_RS04320 966494..968686 + 2193 WP_107552252.1 heavy metal translocating P-type ATPase -
EL095_RS12920 968768..968908 + 141 WP_023016106.1 hypothetical protein -
EL095_RS04325 968968..970176 - 1209 WP_002481760.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T287397 WP_002481764.1 NZ_LR134264:965970-966176 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT287397 WP_002481765.1 NZ_LR134264:965662-965955 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References