Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 879228..879752 Replicon chromosome
Accession NZ_LR134263
Organism Staphylococcus delphini strain NCTC12225

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag EL101_RS03965 Protein ID WP_014613379.1
Coordinates 879399..879752 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag EL101_RS03960 Protein ID WP_014613378.1
Coordinates 879228..879398 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL101_RS03935 875118..875591 + 474 WP_096597952.1 PH domain-containing protein -
EL101_RS03940 875584..877113 + 1530 WP_096597950.1 PH domain-containing protein -
EL101_RS03945 877097..877615 + 519 WP_096597948.1 PH domain-containing protein -
EL101_RS03950 877612..877962 + 351 WP_096597946.1 holo-ACP synthase -
EL101_RS03955 877996..879144 + 1149 WP_096598058.1 alanine racemase -
EL101_RS03960 879228..879398 + 171 WP_014613378.1 hypothetical protein Antitoxin
EL101_RS03965 879399..879752 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL101_RS03970 879810..880814 + 1005 WP_019165832.1 PP2C family protein-serine/threonine phosphatase -
EL101_RS03975 880893..881219 + 327 WP_096597944.1 anti-sigma factor antagonist -
EL101_RS03980 881219..881698 + 480 WP_026067010.1 anti-sigma B factor RsbW -
EL101_RS03985 881673..882443 + 771 WP_096597942.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T287395 WP_014613379.1 NZ_LR134263:879399-879752 [Staphylococcus delphini]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT287395 WP_014613378.1 NZ_LR134263:879228-879398 [Staphylococcus delphini]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References