Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 864824..865345 Replicon chromosome
Accession NZ_LR134263
Organism Staphylococcus delphini strain NCTC12225

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag EL101_RS03895 Protein ID WP_096543014.1
Coordinates 865124..865345 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A2A4GP16
Locus tag EL101_RS03890 Protein ID WP_019165818.1
Coordinates 864824..865111 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL101_RS03865 860085..860888 + 804 WP_096597970.1 hydroxyethylthiazole kinase -
EL101_RS03870 860878..861516 + 639 WP_096598060.1 thiamine phosphate synthase -
EL101_RS03875 861605..862471 + 867 WP_096543018.1 membrane protein insertase YidC -
EL101_RS03880 862525..863181 - 657 WP_096597968.1 HD domain-containing protein -
EL101_RS03885 863202..864692 - 1491 WP_096597966.1 cardiolipin synthase -
EL101_RS03890 864824..865111 + 288 WP_019165818.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL101_RS03895 865124..865345 + 222 WP_096543014.1 heavy-metal-associated domain-containing protein Toxin
EL101_RS03900 865349..865555 + 207 WP_096597964.1 cation transporter -
EL101_RS03905 865656..867836 + 2181 WP_096597962.1 heavy metal translocating P-type ATPase -
EL101_RS03910 868523..869257 + 735 WP_096597960.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8107.18 Da        Isoelectric Point: 4.3480

>T287394 WP_096543014.1 NZ_LR134263:865124-865345 [Staphylococcus delphini]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVVIDLATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11000.61 Da        Isoelectric Point: 6.7507

>AT287394 WP_019165818.1 NZ_LR134263:864824-865111 [Staphylococcus delphini]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIMHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A4GP16

References