Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3933951..3934765 Replicon chromosome
Accession NZ_LR134248
Organism Escherichia coli strain NCTC10537

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag EL141_RS19130 Protein ID WP_001054376.1
Coordinates 3933951..3934208 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag EL141_RS19135 Protein ID WP_001309181.1
Coordinates 3934220..3934765 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL141_RS19110 3929239..3930345 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
EL141_RS19115 3930410..3931390 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EL141_RS19120 3931973..3933213 - 1241 Protein_3719 helicase YjhR -
EL141_RS19125 3933329..3933574 + 246 Protein_3720 GNAT family N-acetyltransferase -
EL141_RS19130 3933951..3934208 + 258 WP_001054376.1 hypothetical protein Toxin
EL141_RS19135 3934220..3934765 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
EL141_RS19140 3934821..3935567 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EL141_RS19145 3935736..3935954 + 219 Protein_3724 hypothetical protein -
EL141_RS22525 3935992..3936108 + 117 Protein_3725 VOC family protein -
EL141_RS19150 3936353..3937474 + 1122 WP_000010829.1 M42 family metallopeptidase -
EL141_RS19155 3937471..3937749 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EL141_RS19160 3937761..3939074 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimE / fimB 3924595..3969723 45128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T287392 WP_001054376.1 NZ_LR134248:3933951-3934208 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT287392 WP_001309181.1 NZ_LR134248:3934220-3934765 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References