287389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3400990..3401827 Replicon chromosome
Accession NZ_LR134248
Organism Escherichia coli strain NCTC10537

Toxin (Protein)


Gene name itaT Uniprot ID A0A140NB16
Locus tag EL141_RS16640 Protein ID WP_000227786.1
Coordinates 3401285..3401827 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag EL141_RS16635 Protein ID WP_001297137.1
Coordinates 3400990..3401301 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL141_RS16610 3396010..3396957 + 948 WP_001239440.1 cytochrome o ubiquinol oxidase subunit II -
EL141_RS16615 3396979..3398970 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
EL141_RS16620 3398960..3399574 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
EL141_RS16625 3399574..3399903 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
EL141_RS16630 3399915..3400805 + 891 WP_000971336.1 heme o synthase -
EL141_RS16635 3400990..3401301 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
EL141_RS16640 3401285..3401827 + 543 WP_000227786.1 GNAT family N-acetyltransferase Toxin
EL141_RS16645 3401883..3402818 - 936 WP_001297127.1 sel1 repeat family protein -
EL141_RS16650 3403235..3404599 + 1365 WP_001000978.1 MFS transporter -
EL141_RS16655 3404727..3405218 - 492 WP_001138904.1 nucleotide binding protein YajQ -
EL141_RS16660 3405386..3406297 + 912 WP_000705853.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19794.98 Da        Isoelectric Point: 8.3395

>T287389 WP_000227786.1 NZ_LR134248:3401285-3401827 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADSAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT287389 WP_001297137.1 NZ_LR134248:3400990-3401301 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140NB16

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References