287372

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3695947..3696565 Replicon chromosome
Accession NZ_LR134247
Organism Escherichia coli strain NCTC9040

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL149_RS18600 Protein ID WP_001291435.1
Coordinates 3696347..3696565 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EL149_RS18595 Protein ID WP_000344800.1
Coordinates 3695947..3696321 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL149_RS18585 3691038..3692231 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL149_RS18590 3692254..3695401 + 3148 Protein_3590 efflux RND transporter permease AcrB -
EL149_RS18595 3695947..3696321 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EL149_RS18600 3696347..3696565 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EL149_RS18605 3696737..3697288 + 552 WP_000102571.1 maltose O-acetyltransferase -
EL149_RS18610 3697404..3697874 + 471 WP_000136192.1 YlaC family protein -
EL149_RS18615 3698038..3699588 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EL149_RS18620 3699630..3699983 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EL149_RS18630 3700362..3700673 + 312 WP_000409911.1 MGMT family protein -
EL149_RS18635 3700704..3701276 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T287372 WP_001291435.1 NZ_LR134247:3696347-3696565 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT287372 WP_000344800.1 NZ_LR134247:3695947-3696321 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References