287367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2618497..2619023 Replicon chromosome
Accession NZ_LR134247
Organism Escherichia coli strain NCTC9040

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL149_RS13245 Protein ID WP_000323025.1
Coordinates 2618497..2618784 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL149_RS13250 Protein ID WP_000534858.1
Coordinates 2618784..2619023 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL149_RS13200 2613521..2613736 - 216 WP_000839590.1 phage lysis protein EssD -
EL149_RS25385 2613956..2614126 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL149_RS13205 2614490..2614705 - 216 WP_000066484.1 cold shock-like protein CspB -
EL149_RS13210 2615006..2615218 + 213 WP_000087756.1 cold shock-like protein CspF -
EL149_RS13215 2615273..2615362 + 90 WP_120795389.1 hypothetical protein -
EL149_RS13220 2615640..2616392 - 753 WP_001047135.1 antitermination protein -
EL149_RS13225 2616406..2617455 - 1050 WP_001265198.1 DUF968 domain-containing protein -
EL149_RS13230 2617457..2617735 - 279 WP_012304870.1 hypothetical protein -
EL149_RS13235 2617802..2618053 - 252 WP_000980994.1 hypothetical protein -
EL149_RS13240 2618270..2618425 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL149_RS13245 2618497..2618784 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL149_RS13250 2618784..2619023 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL149_RS13255 2619048..2619353 + 306 WP_001326990.1 hypothetical protein -
EL149_RS13260 2619556..2619888 + 333 WP_001301033.1 protein FlxA -
EL149_RS13265 2620325..2621638 - 1314 WP_021558774.1 ISNCY family transposase -
EL149_RS25270 2622407..2622694 - 288 Protein_2567 hypothetical protein -
EL149_RS13280 2623305..2623661 - 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL149_RS13285 2623658..2623909 - 252 Protein_2569 DUF977 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2595179..2639275 44096
- inside Prophage - - 2585878..2644404 58526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287367 WP_000323025.1 NZ_LR134247:c2618784-2618497 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287367 WP_000534858.1 NZ_LR134247:c2619023-2618784 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References