Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2618497..2619023 Replicon chromosome
Accession NZ_LR134247
Organism Escherichia coli strain NCTC9040

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL149_RS13245 Protein ID WP_000323025.1
Coordinates 2618497..2618784 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL149_RS13250 Protein ID WP_000534858.1
Coordinates 2618784..2619023 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL149_RS13200 2613521..2613736 - 216 WP_000839590.1 phage lysis protein EssD -
EL149_RS25385 2613956..2614126 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL149_RS13205 2614490..2614705 - 216 WP_000066484.1 cold shock-like protein CspB -
EL149_RS13210 2615006..2615218 + 213 WP_000087756.1 cold shock-like protein CspF -
EL149_RS13215 2615273..2615362 + 90 WP_120795389.1 hypothetical protein -
EL149_RS13220 2615640..2616392 - 753 WP_001047135.1 antitermination protein -
EL149_RS13225 2616406..2617455 - 1050 WP_001265198.1 DUF968 domain-containing protein -
EL149_RS13230 2617457..2617735 - 279 WP_012304870.1 hypothetical protein -
EL149_RS13235 2617802..2618053 - 252 WP_000980994.1 hypothetical protein -
EL149_RS13240 2618270..2618425 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL149_RS13245 2618497..2618784 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL149_RS13250 2618784..2619023 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL149_RS13255 2619048..2619353 + 306 WP_001326990.1 hypothetical protein -
EL149_RS13260 2619556..2619888 + 333 WP_001301033.1 protein FlxA -
EL149_RS13265 2620325..2621638 - 1314 WP_021558774.1 ISNCY family transposase -
EL149_RS25270 2622407..2622694 - 288 Protein_2567 hypothetical protein -
EL149_RS13280 2623305..2623661 - 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL149_RS13285 2623658..2623909 - 252 Protein_2569 DUF977 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2595179..2639275 44096
- inside Prophage - - 2585878..2644404 58526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287367 WP_000323025.1 NZ_LR134247:c2618784-2618497 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287367 WP_000534858.1 NZ_LR134247:c2619023-2618784 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References