Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2432633..2433271 Replicon chromosome
Accession NZ_LR134247
Organism Escherichia coli strain NCTC9040

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EL149_RS12235 Protein ID WP_000813794.1
Coordinates 2432633..2432809 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL149_RS12240 Protein ID WP_001270286.1
Coordinates 2432855..2433271 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL149_RS12215 2428253..2429467 - 1215 WP_001326689.1 BenE family transporter YdcO -
EL149_RS12220 2429520..2430055 + 536 Protein_2362 DNA-binding transcriptional regulator SutR -
EL149_RS12225 2430128..2432089 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL149_RS12230 2432181..2432411 - 231 WP_000494244.1 YncJ family protein -
EL149_RS12235 2432633..2432809 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL149_RS12240 2432855..2433271 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL149_RS12245 2433350..2434756 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
EL149_RS12250 2435001..2436146 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
EL149_RS12255 2436164..2437177 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
EL149_RS25245 2437178..2438117 + 940 Protein_2370 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T287364 WP_000813794.1 NZ_LR134247:2432633-2432809 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT287364 WP_001270286.1 NZ_LR134247:2432855-2433271 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References