287363

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 2209417..2210018 Replicon chromosome
Accession NZ_LR134247
Organism Escherichia coli strain NCTC9040

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag EL149_RS11060 Protein ID WP_001216034.1
Coordinates 2209417..2209797 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag EL149_RS11065 Protein ID WP_001190712.1
Coordinates 2209797..2210018 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL149_RS11035 2204858..2206342 - 1485 WP_000124164.1 terminase -
EL149_RS11040 2206342..2207535 - 1194 WP_126325756.1 terminase -
EL149_RS11045 2207621..2208073 - 453 WP_016231381.1 hypothetical protein -
EL149_RS11050 2208162..2209205 - 1044 WP_126325757.1 DUF968 domain-containing protein -
EL149_RS11055 2209233..2209412 - 180 WP_000113018.1 hypothetical protein -
EL149_RS11060 2209417..2209797 - 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
EL149_RS11065 2209797..2210018 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL149_RS11070 2210201..2211757 + 1557 WP_126325758.1 type I restriction-modification system subunit M -
EL149_RS11075 2211754..2212968 + 1215 WP_126325759.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2175298..2258165 82867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T287363 WP_001216034.1 NZ_LR134247:c2209797-2209417 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT287363 WP_001190712.1 NZ_LR134247:c2210018-2209797 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References