Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 2184979..2185501 Replicon chromosome
Accession NZ_LR134247
Organism Escherichia coli strain NCTC9040

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag EL149_RS10895 Protein ID WP_000220560.1
Coordinates 2184979..2185260 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag EL149_RS10900 Protein ID WP_000121743.1
Coordinates 2185250..2185501 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL149_RS10855 2180513..2180668 - 156 Protein_2092 IS1 family transposase -
EL149_RS10860 2181045..2181944 + 900 Protein_2093 IS5 family transposase -
EL149_RS10875 2183593..2183922 - 330 WP_000866654.1 hypothetical protein -
EL149_RS10880 2184015..2184230 - 216 WP_001180117.1 hypothetical protein -
EL149_RS10885 2184220..2184465 - 246 WP_000356542.1 hypothetical protein -
EL149_RS10890 2184510..2184833 - 324 WP_001181909.1 hypothetical protein -
EL149_RS10895 2184979..2185260 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL149_RS10900 2185250..2185501 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
EL149_RS10910 2186651..2187487 + 837 WP_001575533.1 replication initiation protein -
EL149_RS10915 2187527..2187973 + 447 WP_001074381.1 hypothetical protein -
EL149_RS10920 2188041..2188448 + 408 WP_197719091.1 DNA distortion polypeptide 3 -
EL149_RS10925 2188557..2189537 - 981 WP_213016686.1 IS5-like element IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2175298..2258165 82867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T287362 WP_000220560.1 NZ_LR134247:c2185260-2184979 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT287362 WP_000121743.1 NZ_LR134247:c2185501-2185250 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References