Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 958800..959606 Replicon chromosome
Accession NZ_LR134244
Organism Staphylococcus warneri strain NCTC7291

Toxin (Protein)


Gene name tsbT Uniprot ID A0A364UNB4
Locus tag EL075_RS04745 Protein ID WP_002466824.1
Coordinates 959427..959606 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag EL075_RS04740 Protein ID WP_126403145.1
Coordinates 958800..959399 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL075_RS04720 954601..956061 + 1461 WP_126403143.1 ABC transporter substrate-binding protein/permease -
EL075_RS04725 956054..956776 + 723 WP_002466809.1 amino acid ABC transporter ATP-binding protein -
EL075_RS04730 957019..958149 + 1131 WP_002466804.1 tRNA epoxyqueuosine(34) reductase QueG -
EL075_RS04735 958150..958620 + 471 WP_126403144.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL075_RS04740 958800..959399 + 600 WP_126403145.1 glucosamine-6-phosphate isomerase Antitoxin
EL075_RS04745 959427..959606 + 180 WP_002466824.1 hypothetical protein Toxin
EL075_RS04750 959749..960141 + 393 WP_015364871.1 hypothetical protein -
EL075_RS04755 960296..961681 + 1386 WP_002466811.1 class II fumarate hydratase -
EL075_RS04760 961742..962572 - 831 WP_002466807.1 RluA family pseudouridine synthase -
EL075_RS04765 962750..963862 + 1113 WP_002466816.1 GAF domain-containing sensor histidine kinase -
EL075_RS04770 963883..964506 + 624 WP_002466822.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6901.22 Da        Isoelectric Point: 3.8441

>T287353 WP_002466824.1 NZ_LR134244:959427-959606 [Staphylococcus warneri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22630.53 Da        Isoelectric Point: 4.8492

>AT287353 WP_126403145.1 NZ_LR134244:958800-959399 [Staphylococcus warneri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKVHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNB4

Antitoxin

Source ID Structure

References