Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 820164..820693 Replicon chromosome
Accession NZ_LR134244
Organism Staphylococcus warneri strain NCTC7291

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag EL075_RS03955 Protein ID WP_002451625.1
Coordinates 820331..820693 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag EL075_RS03950 Protein ID WP_002451626.1
Coordinates 820164..820334 (+) Length 57 a.a.

Genomic Context


EL075_RS03925EL075_RS03930EL075_RS03935EL075_RS03940EL075_RS03945EL075_RS03950EL075_RS03955EL075_RS03965EL075_RS03970EL075_RS03975EL075_RS03980
Location: 815989..816462 (474 bp)
Type: Others
Protein ID: WP_002466763.1
Location: 816455..817981 (1527 bp)
Type: Others
Protein ID: WP_002466774.1
Location: 817968..818471 (504 bp)
Type: Others
Protein ID: WP_015364833.1
Location: 818498..818872 (375 bp)
Type: Others
Protein ID: WP_002466788.1
Location: 818924..820072 (1149 bp)
Type: Others
Protein ID: WP_015364834.1
Location: 820164..820334 (171 bp)
Type: Antitoxin
Protein ID: WP_002451626.1
Location: 820331..820693 (363 bp)
Type: Toxin
Protein ID: WP_002451625.1
Location: 821016..822017 (1002 bp)
Type: Others
Protein ID: WP_002466762.1
Location: 822111..822437 (327 bp)
Type: Others
Protein ID: WP_002466754.1
Location: 822439..822918 (480 bp)
Type: Others
Protein ID: WP_002466768.1
Location: 822893..823663 (771 bp)
Type: Others
Protein ID: Protein_785
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL075_RS03925815989..816462+474WP_002466763.1PH domain-containing protein-
EL075_RS03930816455..817981+1527WP_002466774.1PH domain-containing protein-
EL075_RS03935817968..818471+504WP_015364833.1PH domain-containing protein-
EL075_RS03940818498..818872+375WP_002466788.1holo-ACP synthase-
EL075_RS03945818924..820072+1149WP_015364834.1alanine racemase-
EL075_RS03950820164..820334+171WP_002451626.1hypothetical proteinAntitoxin
EL075_RS03955820331..820693+363WP_002451625.1type II toxin-antitoxin system PemK/MazF family toxinToxin
EL075_RS03965821016..822017+1002WP_002466762.1PP2C family protein-serine/threonine phosphatase-
EL075_RS03970822111..822437+327WP_002466754.1anti-sigma factor antagonist-
EL075_RS03975822439..822918+480WP_002466768.1anti-sigma B factor RsbW-
EL075_RS03980822893..823663+771Protein_785RNA polymerase sigma factor SigB-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-109)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T287352 WP_002451625.1 NZ_LR134244:820331-820693 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp


Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT287352 WP_002451626.1 NZ_LR134244:820164-820334 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A2T4PXE7


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2T4PXF4

References