Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 820164..820693 Replicon chromosome
Accession NZ_LR134244
Organism Staphylococcus warneri strain NCTC7291

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag EL075_RS03955 Protein ID WP_002451625.1
Coordinates 820331..820693 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag EL075_RS03950 Protein ID WP_002451626.1
Coordinates 820164..820334 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL075_RS03925 815989..816462 + 474 WP_002466763.1 PH domain-containing protein -
EL075_RS03930 816455..817981 + 1527 WP_002466774.1 PH domain-containing protein -
EL075_RS03935 817968..818471 + 504 WP_015364833.1 PH domain-containing protein -
EL075_RS03940 818498..818872 + 375 WP_002466788.1 holo-ACP synthase -
EL075_RS03945 818924..820072 + 1149 WP_015364834.1 alanine racemase -
EL075_RS03950 820164..820334 + 171 WP_002451626.1 hypothetical protein Antitoxin
EL075_RS03955 820331..820693 + 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL075_RS03965 821016..822017 + 1002 WP_002466762.1 PP2C family protein-serine/threonine phosphatase -
EL075_RS03970 822111..822437 + 327 WP_002466754.1 anti-sigma factor antagonist -
EL075_RS03975 822439..822918 + 480 WP_002466768.1 anti-sigma B factor RsbW -
EL075_RS03980 822893..823663 + 771 Protein_785 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T287352 WP_002451625.1 NZ_LR134244:820331-820693 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT287352 WP_002451626.1 NZ_LR134244:820164-820334 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References