Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 809041..809551 Replicon chromosome
Accession NZ_LR134244
Organism Staphylococcus warneri strain NCTC7291

Toxin (Protein)


Gene name TsdT Uniprot ID A0A364UNH7
Locus tag EL075_RS03895 Protein ID WP_002466743.1
Coordinates 809345..809551 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag EL075_RS03890 Protein ID WP_002466760.1
Coordinates 809041..809334 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL075_RS03865 804167..804958 + 792 WP_126403124.1 hydroxyethylthiazole kinase -
EL075_RS03870 804959..805600 + 642 WP_015364827.1 thiamine phosphate synthase -
EL075_RS03875 805689..806558 + 870 WP_002466746.1 membrane protein insertase YidC -
EL075_RS03880 806596..807240 - 645 WP_002466781.1 HD domain-containing protein -
EL075_RS03885 807368..808852 - 1485 WP_002466786.1 cardiolipin synthase -
EL075_RS03890 809041..809334 + 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL075_RS03895 809345..809551 + 207 WP_002466743.1 heavy-metal-associated domain-containing protein Toxin
EL075_RS03900 809690..809827 + 138 WP_002466770.1 hypothetical protein -
EL075_RS03905 809967..811157 - 1191 WP_002466775.1 rod shape-determining protein RodA -
EL075_RS03910 811515..812585 + 1071 WP_002466764.1 D-alanine--D-alanine ligase -
EL075_RS03915 812601..813962 + 1362 WP_002466757.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7670.62 Da        Isoelectric Point: 3.8601

>T287351 WP_002466743.1 NZ_LR134244:809345-809551 [Staphylococcus warneri]
VQQKIVYTAGIETQEQSEAIKNLLTEMIGVYQVDIDINSGNITIEFETPANLNSIEKEIYDAGYKVLY

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT287351 WP_002466760.1 NZ_LR134244:809041-809334 [Staphylococcus warneri]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNH7

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References