Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 999620..1000426 Replicon chromosome
Accession NZ_LR134242
Organism Staphylococcus warneri strain NCTC4133

Toxin (Protein)


Gene name tsbT Uniprot ID A0A364UNB4
Locus tag EL068_RS04960 Protein ID WP_002466824.1
Coordinates 1000247..1000426 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag EL068_RS04955 Protein ID WP_058710200.1
Coordinates 999620..1000219 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL068_RS04935 995422..996882 + 1461 WP_126510291.1 ABC transporter substrate-binding protein/permease -
EL068_RS04940 996875..997597 + 723 WP_002466809.1 amino acid ABC transporter ATP-binding protein -
EL068_RS04945 997839..998969 + 1131 WP_058710201.1 tRNA epoxyqueuosine(34) reductase QueG -
EL068_RS04950 998970..999440 + 471 WP_002466802.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL068_RS04955 999620..1000219 + 600 WP_058710200.1 hypothetical protein Antitoxin
EL068_RS04960 1000247..1000426 + 180 WP_002466824.1 hypothetical protein Toxin
EL068_RS04965 1000569..1000961 + 393 WP_015364871.1 hypothetical protein -
EL068_RS04970 1001116..1002501 + 1386 WP_058710199.1 class II fumarate hydratase -
EL068_RS04975 1002560..1003390 - 831 WP_002466807.1 RluA family pseudouridine synthase -
EL068_RS04980 1003568..1004680 + 1113 WP_126510292.1 GAF domain-containing sensor histidine kinase -
EL068_RS04985 1004701..1005324 + 624 WP_002466822.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6901.22 Da        Isoelectric Point: 3.8441

>T287346 WP_002466824.1 NZ_LR134242:1000247-1000426 [Staphylococcus warneri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22545.47 Da        Isoelectric Point: 4.9641

>AT287346 WP_058710200.1 NZ_LR134242:999620-1000219 [Staphylococcus warneri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDVSGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNB4

Antitoxin

Source ID Structure

References