Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 848438..848967 Replicon chromosome
Accession NZ_LR134242
Organism Staphylococcus warneri strain NCTC4133

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL068_RS04075 Protein ID WP_058709711.1
Coordinates 848605..848967 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag EL068_RS04070 Protein ID WP_002451626.1
Coordinates 848438..848608 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL068_RS04045 844263..844736 + 474 WP_058709708.1 PH domain-containing protein -
EL068_RS04050 844729..846255 + 1527 WP_058709716.1 PH domain-containing protein -
EL068_RS04055 846242..846745 + 504 WP_126510262.1 PH domain-containing protein -
EL068_RS04060 846772..847146 + 375 WP_058709709.1 holo-ACP synthase -
EL068_RS04065 847198..848346 + 1149 WP_058709710.1 alanine racemase -
EL068_RS04070 848438..848608 + 171 WP_002451626.1 hypothetical protein Antitoxin
EL068_RS04075 848605..848967 + 363 WP_058709711.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL068_RS04085 849290..850291 + 1002 WP_058709712.1 PP2C family protein-serine/threonine phosphatase -
EL068_RS04090 850385..850707 + 323 Protein_805 anti-sigma factor antagonist -
EL068_RS04095 850709..851188 + 480 WP_002466768.1 anti-sigma B factor RsbW -
EL068_RS04100 851163..851933 + 771 Protein_807 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13585.72 Da        Isoelectric Point: 9.9784

>T287345 WP_058709711.1 NZ_LR134242:848605-848967 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFHHSKT

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT287345 WP_002451626.1 NZ_LR134242:848438-848608 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References