287344

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 837315..837825 Replicon chromosome
Accession NZ_LR134242
Organism Staphylococcus warneri strain NCTC4133

Toxin (Protein)


Gene name TsdT Uniprot ID A0A364UNH7
Locus tag EL068_RS04015 Protein ID WP_002466743.1
Coordinates 837619..837825 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag EL068_RS04010 Protein ID WP_002466760.1
Coordinates 837315..837608 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL068_RS03985 832441..833232 + 792 WP_058709701.1 hydroxyethylthiazole kinase -
EL068_RS03990 833233..833874 + 642 WP_058709702.1 thiamine phosphate synthase -
EL068_RS03995 833963..834832 + 870 WP_002466746.1 membrane protein insertase YidC -
EL068_RS04000 834870..835514 - 645 WP_058709703.1 HD domain-containing protein -
EL068_RS04005 835642..837126 - 1485 WP_058709704.1 cardiolipin synthase -
EL068_RS04010 837315..837608 + 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL068_RS04015 837619..837825 + 207 WP_002466743.1 heavy-metal-associated domain-containing protein Toxin
EL068_RS04020 837964..838101 + 138 WP_002466770.1 hypothetical protein -
EL068_RS04025 838241..839431 - 1191 WP_002466775.1 rod shape-determining protein RodA -
EL068_RS04030 839789..840859 + 1071 WP_002466764.1 D-alanine--D-alanine ligase -
EL068_RS04035 840875..842236 + 1362 WP_058709706.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7670.62 Da        Isoelectric Point: 3.8601

>T287344 WP_002466743.1 NZ_LR134242:837619-837825 [Staphylococcus warneri]
VQQKIVYTAGIETQEQSEAIKNLLTEMIGVYQVDIDINSGNITIEFETPANLNSIEKEIYDAGYKVLY

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT287344 WP_002466760.1 NZ_LR134242:837315-837608 [Staphylococcus warneri]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNH7

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References