Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4269880..4270377 Replicon chromosome
Accession NZ_LR134240
Organism Escherichia coli strain NCTC9107

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag EL129_RS20955 Protein ID WP_001173343.1
Coordinates 4269880..4270053 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag EL129_RS20960 Protein ID WP_000398619.1
Coordinates 4270081..4270377 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL129_RS20945 4266550..4268007 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
EL129_RS20950 4268244..4269761 + 1518 WP_001295074.1 lysine--tRNA ligase -
EL129_RS20955 4269880..4270053 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
EL129_RS20960 4270081..4270377 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
EL129_RS20965 4270604..4270876 - 273 WP_000405651.1 N-acetyltransferase -
EL129_RS20970 4270888..4271118 - 231 WP_000371704.1 (4Fe-4S)-binding protein -
EL129_RS20975 4271299..4272930 + 1632 WP_001216477.1 sensor histidine kinase -
EL129_RS20980 4272927..4273646 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T287342 WP_001173343.1 NZ_LR134240:c4270053-4269880 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT287342 WP_000398619.1 NZ_LR134240:c4270377-4270081 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References