Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2275963..2276489 Replicon chromosome
Accession NZ_LR134240
Organism Escherichia coli strain NCTC9107

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL129_RS11120 Protein ID WP_000323025.1
Coordinates 2276202..2276489 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL129_RS11115 Protein ID WP_000534858.1
Coordinates 2275963..2276202 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL129_RS11080 2271175..2271525 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
EL129_RS11085 2271522..2271947 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
EL129_RS23310 2272292..2272579 + 288 Protein_2133 hypothetical protein -
EL129_RS11100 2273348..2274661 + 1314 WP_000589005.1 ISNCY family transposase -
EL129_RS11105 2275098..2275430 - 333 WP_001301033.1 protein FlxA -
EL129_RS11110 2275633..2275938 - 306 WP_001326990.1 hypothetical protein -
EL129_RS11115 2275963..2276202 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL129_RS11120 2276202..2276489 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL129_RS11125 2276561..2276716 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL129_RS11130 2276933..2277184 + 252 WP_000980994.1 hypothetical protein -
EL129_RS11135 2277251..2277529 + 279 WP_012304870.1 hypothetical protein -
EL129_RS11140 2277531..2278580 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL129_RS11145 2278594..2279346 + 753 WP_001556615.1 antitermination protein -
EL129_RS11150 2279624..2279713 - 90 WP_120795389.1 hypothetical protein -
EL129_RS11155 2279768..2279980 - 213 WP_000087756.1 cold shock-like protein CspF -
EL129_RS11160 2280281..2280496 + 216 WP_000066484.1 cold shock-like protein CspB -
EL129_RS23435 2280860..2281030 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL129_RS11165 2281251..2281466 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2247213..2320271 73058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287334 WP_000323025.1 NZ_LR134240:2276202-2276489 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287334 WP_000534858.1 NZ_LR134240:2275963-2276202 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References