287334

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2275963..2276489 Replicon chromosome
Accession NZ_LR134240
Organism Escherichia coli strain NCTC9107

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL129_RS11120 Protein ID WP_000323025.1
Coordinates 2276202..2276489 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL129_RS11115 Protein ID WP_000534858.1
Coordinates 2275963..2276202 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL129_RS11080 2271175..2271525 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
EL129_RS11085 2271522..2271947 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
EL129_RS23310 2272292..2272579 + 288 Protein_2133 hypothetical protein -
EL129_RS11100 2273348..2274661 + 1314 WP_000589005.1 ISNCY family transposase -
EL129_RS11105 2275098..2275430 - 333 WP_001301033.1 protein FlxA -
EL129_RS11110 2275633..2275938 - 306 WP_001326990.1 hypothetical protein -
EL129_RS11115 2275963..2276202 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL129_RS11120 2276202..2276489 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL129_RS11125 2276561..2276716 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL129_RS11130 2276933..2277184 + 252 WP_000980994.1 hypothetical protein -
EL129_RS11135 2277251..2277529 + 279 WP_012304870.1 hypothetical protein -
EL129_RS11140 2277531..2278580 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL129_RS11145 2278594..2279346 + 753 WP_001556615.1 antitermination protein -
EL129_RS11150 2279624..2279713 - 90 WP_120795389.1 hypothetical protein -
EL129_RS11155 2279768..2279980 - 213 WP_000087756.1 cold shock-like protein CspF -
EL129_RS11160 2280281..2280496 + 216 WP_000066484.1 cold shock-like protein CspB -
EL129_RS23435 2280860..2281030 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL129_RS11165 2281251..2281466 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2247213..2320271 73058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287334 WP_000323025.1 NZ_LR134240:2276202-2276489 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287334 WP_000534858.1 NZ_LR134240:2275963-2276202 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References