Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 714994..715619 Replicon chromosome
Accession NC_020089
Organism Mycobacterium tuberculosis 7199-99

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MT7199_RS03235 Protein ID WP_003403218.1
Coordinates 715218..715619 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MT7199_RS03230 Protein ID WP_003403213.1
Coordinates 714994..715221 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT7199_RS03200 710173..710394 - 222 WP_003898525.1 DUF4926 domain-containing protein -
MT7199_RS03205 710536..711141 + 606 WP_003898526.1 hypothetical protein -
MT7199_RS03210 711160..713727 - 2568 WP_003900188.1 SEC-C domain-containing protein -
MT7199_RS03215 713811..714560 + 750 WP_003898528.1 hypothetical protein -
MT7199_RS03220 714557..714799 + 243 WP_003403210.1 hypothetical protein -
MT7199_RS03230 714994..715221 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MT7199_RS03235 715218..715619 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MT7199_RS20835 715748..716443 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
MT7199_RS20840 716440..716931 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
MT7199_RS03245 716928..718019 + 1092 WP_003906403.1 galactokinase -
MT7199_RS03255 718414..719478 + 1065 WP_003898532.1 hypothetical protein -
MT7199_RS03260 719582..720529 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T28733 WP_003403218.1 NC_020089:715218-715619 [Mycobacterium tuberculosis 7199-99]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T28733 NC_020089:715218-715619 [Mycobacterium tuberculosis 7199-99]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT28733 WP_003403213.1 NC_020089:714994-715221 [Mycobacterium tuberculosis 7199-99]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT28733 NC_020089:714994-715221 [Mycobacterium tuberculosis 7199-99]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References