Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 940795..941449 Replicon chromosome
Accession NZ_LR134240
Organism Escherichia coli strain NCTC9107

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag EL129_RS04665 Protein ID WP_000244781.1
Coordinates 941042..941449 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag EL129_RS04660 Protein ID WP_000354046.1
Coordinates 940795..941061 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL129_RS04640 936883..938316 - 1434 WP_024210543.1 6-phospho-beta-glucosidase BglA -
EL129_RS04645 938361..938672 + 312 WP_001182958.1 N(4)-acetylcytidine aminohydrolase -
EL129_RS04650 938836..939495 + 660 WP_000250269.1 hemolysin III family protein -
EL129_RS04655 939572..940552 - 981 WP_000886075.1 tRNA-modifying protein YgfZ -
EL129_RS04660 940795..941061 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
EL129_RS04665 941042..941449 + 408 WP_000244781.1 protein YgfX Toxin
EL129_RS04670 941489..942010 - 522 WP_001055872.1 flavodoxin FldB -
EL129_RS04675 942122..943018 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EL129_RS04680 943043..943753 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL129_RS04685 943759..945492 + 1734 WP_000813176.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T287327 WP_000244781.1 NZ_LR134240:941042-941449 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT287327 WP_000354046.1 NZ_LR134240:940795-941061 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References