Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 839211..840045 Replicon chromosome
Accession NZ_LR134240
Organism Escherichia coli strain NCTC9107

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3TJB4
Locus tag EL129_RS04065 Protein ID WP_000854811.1
Coordinates 839211..839588 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EL129_RS04070 Protein ID WP_126324601.1
Coordinates 839677..840045 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL129_RS04045 837009..838229 + 1221 WP_000794251.1 capsular biosynthesis protein -
EL129_RS04050 838252..838488 - 237 WP_000986719.1 hypothetical protein -
EL129_RS04055 838591..838767 - 177 WP_000839288.1 DUF957 domain-containing protein -
EL129_RS04060 838784..839214 - 431 Protein_792 hypothetical protein -
EL129_RS04065 839211..839588 - 378 WP_000854811.1 type IV toxin-antitoxin system toxin CbtA Toxin
EL129_RS04070 839677..840045 - 369 WP_126324601.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EL129_RS04075 840119..840340 - 222 WP_000692300.1 DUF987 domain-containing protein -
EL129_RS04080 840409..840885 - 477 WP_001186725.1 RadC family protein -
EL129_RS04085 840901..841386 - 486 WP_000214310.1 antirestriction protein -
EL129_RS04090 841478..842296 - 819 WP_061354001.1 DUF945 domain-containing protein -
EL129_RS04100 842451..842609 - 159 WP_001556217.1 DUF905 family protein -
EL129_RS04105 842688..843143 - 456 WP_001556216.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14041.14 Da        Isoelectric Point: 7.8839

>T287326 WP_000854811.1 NZ_LR134240:c839588-839211 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13661.55 Da        Isoelectric Point: 6.9552

>AT287326 WP_126324601.1 NZ_LR134240:c840045-839677 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPRTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3TJB4

Antitoxin

Source ID Structure

References