Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2223136..2223662 Replicon chromosome
Accession NZ_LR134239
Organism Escherichia coli strain NCTC9100

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL124_RS10825 Protein ID WP_000323025.1
Coordinates 2223375..2223662 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL124_RS10820 Protein ID WP_000534858.1
Coordinates 2223136..2223375 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL124_RS10785 2218250..2218501 + 252 Protein_2093 DUF977 family protein -
EL124_RS10790 2218498..2218854 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL124_RS22095 2219465..2219752 + 288 Protein_2095 hypothetical protein -
EL124_RS10805 2220521..2221834 + 1314 WP_000589005.1 ISNCY family transposase -
EL124_RS10810 2222271..2222603 - 333 WP_001301033.1 protein FlxA -
EL124_RS10815 2222806..2223111 - 306 WP_001326990.1 hypothetical protein -
EL124_RS10820 2223136..2223375 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL124_RS10825 2223375..2223662 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL124_RS10830 2223734..2223889 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL124_RS10835 2224106..2224357 + 252 WP_000980994.1 hypothetical protein -
EL124_RS10840 2224424..2224702 + 279 WP_012304870.1 hypothetical protein -
EL124_RS10845 2224704..2225753 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL124_RS10850 2225767..2226519 + 753 WP_001047135.1 antitermination protein -
EL124_RS10855 2226797..2226886 - 90 WP_120795389.1 hypothetical protein -
EL124_RS10860 2226941..2227153 - 213 WP_000087756.1 cold shock-like protein CspF -
EL124_RS10865 2227454..2227669 + 216 WP_000066484.1 cold shock-like protein CspB -
EL124_RS22215 2228033..2228203 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL124_RS10870 2228423..2228638 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2201590..2239415 37825


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287316 WP_000323025.1 NZ_LR134239:2223375-2223662 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287316 WP_000534858.1 NZ_LR134239:2223136-2223375 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References