Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 972360..972943 Replicon chromosome
Accession NZ_LR134239
Organism Escherichia coli strain NCTC9100

Toxin (Protein)


Gene name mazF Uniprot ID S1EZP4
Locus tag EL124_RS04725 Protein ID WP_000254738.1
Coordinates 972608..972943 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag EL124_RS04720 Protein ID WP_000581937.1
Coordinates 972360..972608 (+) Length 83 a.a.

Genomic Context

EL124_RS04710EL124_RS04715EL124_RS04720EL124_RS04725EL124_RS04730EL124_RS04735EL124_RS04740
Location: 968699..970000 (1302 bp)
Type: Others
Protein ID: WP_000046812.1
Location: 970048..972282 (2235 bp)
Type: Others
Protein ID: WP_032176554.1
Location: 972360..972608 (249 bp)
Type: Antitoxin
Protein ID: WP_000581937.1
Location: 972608..972943 (336 bp)
Type: Toxin
Protein ID: WP_000254738.1
Location: 973014..973805 (792 bp)
Type: Others
Protein ID: WP_001071648.1
Location: 974033..975670 (1638 bp)
Type: Others
Protein ID: WP_000210878.1
Location: 975758..977056 (1299 bp)
Type: Others
Protein ID: WP_000036723.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL124_RS04710968699..970000+1302WP_000046812.123S rRNA (uracil(1939)-C(5))-methyltransferase RlmD-
EL124_RS04715970048..972282+2235WP_032176554.1GTP diphosphokinase-
EL124_RS04720972360..972608+249WP_000581937.1type II toxin-antitoxin system antitoxin MazEAntitoxin
EL124_RS04725972608..972943+336WP_000254738.1endoribonuclease MazFToxin
EL124_RS04730973014..973805+792WP_001071648.1nucleoside triphosphate pyrophosphohydrolase-
EL124_RS04735974033..975670+1638WP_000210878.1CTP synthase (glutamine hydrolyzing)-
EL124_RS04740975758..977056+1299WP_000036723.1phosphopyruvate hydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12098.04 Da        Isoelectric Point: 8.2618

>T287310 WP_000254738.1 NZ_LR134239:972608-972943 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT287310 WP_000581937.1 NZ_LR134239:972360-972608 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB1UB4
PDB5CQX
PDB5CK9
PDB5CKH
PDB5CO7
PDB3NFC
PDB5CR2
PDB5CKB
PDB5CQY
PDB5CKD
PDB5CKE
PDB5CKF

Antitoxin

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Source
ID
Structure
PDB1UB4
PDB5CQX
PDB5CQY
PDB1MVF
PDB2MRN
PDB2MRU
AlphaFold DBA0A7U9LMB4

References