Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 701366..702012 Replicon chromosome
Accession NC_020089
Organism Mycobacterium tuberculosis 7199-99

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag MT7199_RS03125 Protein ID WP_003403137.1
Coordinates 701366..701779 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag MT7199_RS03130 Protein ID WP_003403139.1
Coordinates 701776..702012 (-) Length 79 a.a.

Genomic Context

MT7199_RS03105MT7199_RS03150MT7199_RS03155MT7199_RS03160MT7199_RS03165MT7199_RS03110MT7199_RS03115MT7199_RS03120MT7199_RS03125MT7199_RS03130MT7199_RS03135MT7199_RS03140MT7199_RS03145
Location: 697449..698999 (1551 bp)
Type: Others
Protein ID: WP_003403119.1
Location: 704068..704379 (312 bp)
Type: Others
Protein ID: WP_003403164.1
Location: 704451..705401 (951 bp)
Type: Others
Protein ID: WP_003900184.1
Location: 705642..706226 (585 bp)
Type: Others
Protein ID: WP_003403171.1
Location: 706228..706938 (711 bp)
Type: Others
Protein ID: Protein_629
Location: 699051..699443 (393 bp)
Type: Others
Protein ID: WP_003403122.1
Location: 699440..699697 (258 bp)
Type: Others
Protein ID: WP_003403125.1
Location: 699880..701115 (1236 bp)
Type: Others
Protein ID: WP_003403128.1
Location: 701366..701779 (414 bp)
Type: Toxin
Protein ID: WP_003403137.1
Location: 701776..702012 (237 bp)
Type: Antitoxin
Protein ID: WP_003403139.1
Location: 702116..702622 (507 bp)
Type: Others
Protein ID: WP_003900973.1
Location: 702736..703266 (531 bp)
Type: Others
Protein ID: WP_003917320.1
Location: 703250..703945 (696 bp)
Type: Others
Protein ID: WP_003918099.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MT7199_RS03105697449..698999+1551WP_003403119.1MCE family protein-
MT7199_RS03110699051..699443-393WP_003403122.1type II toxin-antitoxin system toxin ribonuclease C4-
MT7199_RS03115699440..699697-258WP_003403125.1type II toxin-antitoxin system antitoxin VapB4-
MT7199_RS03120699880..701115-1236WP_003403128.1ATP-binding protein-
MT7199_RS03125701366..701779-414WP_003403137.1type II toxin-antitoxin system VapC family toxinToxin
MT7199_RS03130701776..702012-237WP_003403139.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MT7199_RS03135702116..702622-507WP_003900973.1two component system sensor kinase HK1-
MT7199_RS03140702736..703266-531WP_003917320.1two component system sensor kinase HK2-
MT7199_RS03145703250..703945-696WP_003918099.1two-component system response regulator TcrA-
MT7199_RS03150704068..704379+312WP_003403164.1hypothetical protein-
MT7199_RS03155704451..705401+951WP_003900184.1DUF1259 domain-containing protein-
MT7199_RS03160705642..706226+585WP_003403171.1IS607-like element IS1536 family transposase-
MT7199_RS03165706228..706938+711Protein_629transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(3-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T28731 WP_003403137.1 NC_020089:c701779-701366 [Mycobacterium tuberculosis 7199-99]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T28731 NC_020089:c701779-701366 [Mycobacterium tuberculosis 7199-99]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT28731 WP_003403139.1 NC_020089:c702012-701776 [Mycobacterium tuberculosis 7199-99]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT28731 NC_020089:c702012-701776 [Mycobacterium tuberculosis 7199-99]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TQ88

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TQ89

References