Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4643466..4643963 Replicon chromosome
Accession NZ_LR134237
Organism Escherichia coli strain NCTC9022

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag EL138_RS23015 Protein ID WP_001173343.1
Coordinates 4643466..4643639 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag EL138_RS23020 Protein ID WP_001312331.1
Coordinates 4643667..4643963 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL138_RS23005 4640136..4641593 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
EL138_RS23010 4641830..4643347 + 1518 WP_000003806.1 lysine--tRNA ligase -
EL138_RS23015 4643466..4643639 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
EL138_RS23020 4643667..4643963 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
EL138_RS23025 4644192..4644464 - 273 WP_000405647.1 N-acetyltransferase -
EL138_RS23030 4644476..4644706 - 231 WP_000371715.1 (4Fe-4S)-binding protein -
EL138_RS23035 4644887..4646518 + 1632 WP_001216466.1 sensor histidine kinase -
EL138_RS23040 4646515..4647234 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4575974..4643963 67989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T287304 WP_001173343.1 NZ_LR134237:c4643639-4643466 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT287304 WP_001312331.1 NZ_LR134237:c4643963-4643667 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References