Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3758704..3759322 Replicon chromosome
Accession NZ_LR134237
Organism Escherichia coli strain NCTC9022

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL138_RS18730 Protein ID WP_001291435.1
Coordinates 3759104..3759322 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EL138_RS18725 Protein ID WP_000344800.1
Coordinates 3758704..3759078 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL138_RS18715 3753794..3754987 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL138_RS18720 3755010..3758159 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
EL138_RS18725 3758704..3759078 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EL138_RS18730 3759104..3759322 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EL138_RS18735 3759495..3760046 + 552 WP_000102539.1 maltose O-acetyltransferase -
EL138_RS18740 3760162..3760632 + 471 WP_001304825.1 YlaC family protein -
EL138_RS18745 3760796..3762346 + 1551 WP_001528761.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EL138_RS18750 3762388..3762741 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EL138_RS18760 3763120..3763431 + 312 WP_000409908.1 MGMT family protein -
EL138_RS18765 3763462..3764034 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T287295 WP_001291435.1 NZ_LR134237:3759104-3759322 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT287295 WP_000344800.1 NZ_LR134237:3758704-3759078 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References