Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
| Location | 4113977..4114791 | Replicon | chromosome |
| Accession | NZ_LR134236 | ||
| Organism | Escherichia coli strain NCTC9008 | ||
Toxin (Protein)
| Gene name | yjhX | Uniprot ID | S1PA82 |
| Locus tag | EL127_RS20165 | Protein ID | WP_001054376.1 |
| Coordinates | 4113977..4114234 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yjhQ | Uniprot ID | B7MMJ3 |
| Locus tag | EL127_RS20170 | Protein ID | WP_001338189.1 |
| Coordinates | 4114246..4114791 (+) | Length | 182 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EL127_RS20145 | 4109265..4110371 | + | 1107 | WP_001299704.1 | N-acetylneuraminate epimerase | - |
| EL127_RS20150 | 4110436..4111416 | + | 981 | WP_126497089.1 | sialate O-acetylesterase | - |
| EL127_RS20155 | 4111999..4113239 | - | 1241 | Protein_3913 | helicase YjhR | - |
| EL127_RS20160 | 4113355..4113600 | + | 246 | Protein_3914 | GNAT family N-acetyltransferase | - |
| EL127_RS20165 | 4113977..4114234 | + | 258 | WP_001054376.1 | hypothetical protein | Toxin |
| EL127_RS20170 | 4114246..4114791 | + | 546 | WP_001338189.1 | N-acetyltransferase | Antitoxin |
| EL127_RS20175 | 4114847..4115593 | + | 747 | WP_000354251.1 | class I SAM-dependent methyltransferase | - |
| EL127_RS20180 | 4115762..4115980 | + | 219 | Protein_3918 | hypothetical protein | - |
| EL127_RS23425 | 4116018..4116134 | + | 117 | Protein_3919 | VOC family protein | - |
| EL127_RS20185 | 4116379..4117500 | + | 1122 | WP_126497090.1 | M42 family metallopeptidase | - |
| EL127_RS20190 | 4117497..4117775 | + | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB | - |
| EL127_RS20195 | 4117787..4119100 | + | 1314 | WP_000460843.1 | galactitol-specific PTS transporter subunit IIC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimE / fimB | 4105401..4123015 | 17614 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9734.29 Da Isoelectric Point: 11.0090
>T287281 WP_001054376.1 NZ_LR134236:4113977-4114234 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
Download Length: 258 bp
Antitoxin
Download Length: 182 a.a. Molecular weight: 19986.92 Da Isoelectric Point: 6.3277
>AT287281 WP_001338189.1 NZ_LR134236:4114246-4114791 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
Download Length: 546 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1PA82 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2KXJ3 |