Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 644434..645110 Replicon chromosome
Accession NC_020089
Organism Mycobacterium tuberculosis 7199-99

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag MT7199_RS02875 Protein ID WP_003898500.1
Coordinates 644434..644847 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag MT7199_RS02880 Protein ID WP_003402915.1
Coordinates 644844..645110 (-) Length 89 a.a.

Genomic Context

MT7199_RS02890MT7199_RS02895MT7199_RS02845MT7199_RS02850MT7199_RS02855MT7199_RS02860MT7199_RS02865MT7199_RS02870MT7199_RS02875MT7199_RS02880MT7199_RS02885
Location: 647095..648699 (1605 bp)
Type: Others
Protein ID: WP_003402920.1
Location: 648696..649676 (981 bp)
Type: Others
Protein ID: WP_003402923.1
Location: 639779..640081 (303 bp)
Type: Others
Protein ID: WP_003402896.1
Location: 640141..640419 (279 bp)
Type: Others
Protein ID: WP_003402901.1
Location: 640416..641669 (1254 bp)
Type: Others
Protein ID: WP_003402904.1
Location: 641789..642175 (387 bp)
Type: Others
Protein ID: WP_003402907.1
Location: 642238..643122 (885 bp)
Type: Others
Protein ID: WP_003402909.1
Location: 643218..644120 (903 bp)
Type: Others
Protein ID: WP_003915439.1
Location: 644434..644847 (414 bp)
Type: Toxin
Protein ID: WP_003898500.1
Location: 644844..645110 (267 bp)
Type: Antitoxin
Protein ID: WP_003402915.1
Location: 645302..647017 (1716 bp)
Type: Others
Protein ID: WP_003402917.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MT7199_RS02845639779..640081-303WP_003402896.1DUF3349 domain-containing protein-
MT7199_RS02850640141..640419-279WP_003402901.1hypothetical protein-
MT7199_RS02855640416..641669-1254WP_003402904.1inorganic phosphate transporter family protein-
MT7199_RS02860641789..642175-387WP_003402907.1VOC family protein-
MT7199_RS02865642238..643122-885WP_003402909.1SDR family oxidoreductase-
MT7199_RS02870643218..644120-903WP_003915439.11,4-dihydroxy-2-naphthoyl-CoA synthase-
MT7199_RS02875644434..644847-414WP_003898500.1PIN domain-containing proteinToxin
MT7199_RS02880644844..645110-267WP_003402915.1antitoxin VapB3Antitoxin
MT7199_RS02885645302..647017-1716WP_003402917.1fatty-acid--CoA ligase FadD8-
MT7199_RS02890647095..648699+1605WP_003402920.1amidohydrolase-
MT7199_RS02895648696..649676+981WP_003402923.1o-succinylbenzoate synthase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T28728 WP_003898500.1 NC_020089:c644847-644434 [Mycobacterium tuberculosis 7199-99]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T28728 NC_020089:c644847-644434 [Mycobacterium tuberculosis 7199-99]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT28728 WP_003402915.1 NC_020089:c645110-644844 [Mycobacterium tuberculosis 7199-99]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT28728 NC_020089:c645110-644844 [Mycobacterium tuberculosis 7199-99]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TPQ9

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TPR0

References