Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2491406..2492044 Replicon chromosome
Accession NZ_LR134236
Organism Escherichia coli strain NCTC9008

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EL127_RS12135 Protein ID WP_000813794.1
Coordinates 2491868..2492044 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL127_RS12130 Protein ID WP_001270286.1
Coordinates 2491406..2491822 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL127_RS12110 2486558..2487499 - 942 WP_001251313.1 ABC transporter permease -
EL127_RS12115 2487500..2488513 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
EL127_RS12120 2488531..2489676 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
EL127_RS12125 2489921..2491327 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
EL127_RS12130 2491406..2491822 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL127_RS12135 2491868..2492044 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL127_RS12140 2492266..2492496 + 231 WP_000494244.1 YncJ family protein -
EL127_RS12145 2492588..2494549 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL127_RS12150 2494622..2495158 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
EL127_RS12155 2495211..2495867 + 657 Protein_2358 BenE family transporter YdcO -
EL127_RS12160 2495884..2496581 - 698 Protein_2359 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2491406..2507958 16552


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T287274 WP_000813794.1 NZ_LR134236:c2492044-2491868 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT287274 WP_001270286.1 NZ_LR134236:c2491822-2491406 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References