Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2353583..2354109 Replicon chromosome
Accession NZ_LR134236
Organism Escherichia coli strain NCTC9008

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL127_RS11465 Protein ID WP_000323025.1
Coordinates 2353822..2354109 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL127_RS11460 Protein ID WP_000534858.1
Coordinates 2353583..2353822 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL127_RS11430 2348945..2349301 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL127_RS23390 2349912..2350199 + 288 Protein_2214 hypothetical protein -
EL127_RS11445 2350968..2352281 + 1314 WP_000589005.1 ISNCY family transposase -
EL127_RS11450 2352718..2353050 - 333 WP_001301033.1 protein FlxA -
EL127_RS11455 2353253..2353558 - 306 WP_001326990.1 hypothetical protein -
EL127_RS11460 2353583..2353822 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL127_RS11465 2353822..2354109 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL127_RS11470 2354181..2354336 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL127_RS11475 2354553..2354804 + 252 WP_000980994.1 hypothetical protein -
EL127_RS11480 2354871..2355149 + 279 WP_012304870.1 hypothetical protein -
EL127_RS11485 2355151..2356200 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL127_RS11490 2356214..2356966 + 753 WP_096306159.1 antitermination protein -
EL127_RS11495 2357244..2357333 - 90 WP_120795389.1 hypothetical protein -
EL127_RS11500 2357388..2357600 - 213 WP_000087756.1 cold shock-like protein CspF -
EL127_RS11505 2357901..2358116 + 216 WP_000066484.1 cold shock-like protein CspB -
EL127_RS23515 2358480..2358650 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL127_RS11510 2358870..2359085 + 216 WP_096306160.1 class II holin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2328711..2369231 40520
- inside Prophage - - 2335304..2369231 33927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287272 WP_000323025.1 NZ_LR134236:2353822-2354109 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287272 WP_000534858.1 NZ_LR134236:2353583-2353822 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References