Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5661377..5662965 Replicon chromosome
Accession NZ_LR134235
Organism Klebsiella variicola strain NCTC9668

Toxin (Protein)


Gene name hipA Uniprot ID A0A1F2MCM0
Locus tag EL159_RS27975 Protein ID WP_008804919.1
Coordinates 5661377..5662699 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag EL159_RS27980 Protein ID WP_008804920.1
Coordinates 5662699..5662965 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL159_RS27960 5656442..5658943 + 2502 WP_050887168.1 fimbrial biogenesis outer membrane usher protein -
EL159_RS27965 5658931..5659935 + 1005 WP_008804917.1 type 1 fimbrial protein -
EL159_RS27970 5660068..5661360 + 1293 WP_126315612.1 glycoside hydrolase family 10 protein -
EL159_RS27975 5661377..5662699 - 1323 WP_008804919.1 type II toxin-antitoxin system HipA family toxin Toxin
EL159_RS27980 5662699..5662965 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EL159_RS27985 5663231..5663557 - 327 WP_008804921.1 hydroxyisourate hydrolase -
EL159_RS27990 5663554..5664054 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EL159_RS27995 5664032..5665411 - 1380 WP_012968246.1 purine permease -
EL159_RS28000 5665757..5666911 + 1155 WP_023322603.1 FAD-dependent urate hydroxylase HpxO -
EL159_RS28005 5666892..5667815 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48911.26 Da        Isoelectric Point: 7.9109

>T287259 WP_008804919.1 NZ_LR134235:c5662699-5661377 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT287259 WP_008804920.1 NZ_LR134235:c5662965-5662699 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2MCM0

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References